Formaldehyde dehydrogenase, glutathione-independent <p>Members of this entry represent a distinct clade within the larger family of zinc-dependent dehydrogenases of medium chain alcohols. This entry includes the so-called glutathione-dependent formaldehyde dehydrogenase. Members of this entry have a tightly bound NAD that can act as a true cofactor, rather than a co-substrate in dehydrogenase reactions and in dismutase reactions for some aldehydes. The name given to this family, however, is formaldehyde dehydrogenase, glutathione-independent.</p>